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Tyrosinase Catalyzed - China

price: 1.00 Euro €

The Chinese - to a greater extent, East Asians have always believed in "a white cover." It is true that most people are not so enthusiastic about the pursuit of "white", but they often hate the stains, including Westerners who "black for beauty": color uniformity has always been regarded as one of the criteria for healthy and beautiful skin.
Whether it is stain or dark skin, it is related to melanin. The melanin bodies in melanocytes contain melanin and are therefore black. Analysis of the superficial stratum corneum of the yellow exposed area and the non-exposed area revealed that the skin surface of the exposed area contained more melanin, which proved that sunlight was related to darkening of the skin. More specifically, ultraviolet rays in sunlight darken the skin. When ultraviolet light (usually UVA and UVB reaching the surface) is irradiated onto the skin, it will cause a large amount of free radicals, inflammatory factor release, collagen damage and even DNA breakage. Due to the "instinct" of self-protection, the skin produces a lot of melanin to absorb ultraviolet rays. When exposed to ultraviolet light, melanin is oxidized by oxygen radicals generated by UVA to darker oxidized melanin, redistributed, and the skin tone immediately becomes dull. The skin will be prepared for the rainy day, and work overtime for a long time to create more melanin, so as not to be caught off guard next time. The “results” of self-protection last for a while, meaning that the skin is darker than before in the months after the sun, which is really not good.
Compared with the normal area with even skin tone, the melanocytes in the pigmented area are more active, and the source continuously supplies melanin from the bottom of the epidermis, resulting in persistent pigment accumulation. For the same reason as blackening, the stains are also aggravated by sunlight.
How is the melanin in the skin synthesized? The determining step in melanin synthesis is the conversion of tyrosine to dopa under the action of tyrosinase. Tyrosine is an essential amino acid for human physiological activities and is abundantly and widely present in humans. The tyrosinase activity in darker skin is about three times that of skin with lighter skin. The most critical step in controlling skin blackening is to find a way to block the effects of tyrosinase. Ethyl cinnamate not only inhibits the activity of tyrosinase, but also blocks certain ultraviolet rays, so that melanin is no longer increased, and the absorption rate is high, it is completely non-irritating to the skin, and the safety is very high. It is used to prepare sunscreen (paste, Skin care cosmetics such as milk and liquid can prevent sunburn, sunburn and tanning of human skin, so that the range of color spots is no longer enlarged, and the skin color is no longer deeper. Tyrosinase, also known as polyphenol oxidase, is widely found in plants, animals and humans. It is a key enzyme in the synthesis of melanin by organisms. Tyrosinase inhibitors inhibit melanin production by inhibiting tyrosinase activity, and thus can be used to prevent and treat diseases such as pigmentation and melanoma. At present, tyrosinase inhibitors such as hydroquinone, fruit acid, vitamin C, kojic acid, and arbutin have been used as a whitening agent in cosmetics, but hydroquinone and fruit acids have gradually been eliminated due to irritation; vitamin C Kojic acid is easily oxidized and has a short shelf life. Arbutin is widely used as a plant extract because it has the advantages of safe action. However, the inhibitory effect of tyrosinase is not strong. The amount of arbutin added in cosmetics should be as high as 2% or more. effective. Therefore, the development of safe and efficient tyrosinase inhibitors has increasingly attracted people's attention. Experts in the study found that methyl cinnamate has a significant inhibitory effect on tyrosinase, can inhibit the activity of tyrosinase monophenols and diphenols enzyme activity. The inhibitory effect of monophenolase on tyrosinase was mainly manifested in the significant prolongation of the lag time of enzyme-catalyzed reaction, and the inhibitory effect on diphenolase showed a type of reversible competitive inhibition with an inhibitory constant (K) of I 0.66 mmol. /L, the methyl cinnamate concentration (IC50) with a relative inhibition rate of 50% for p-diphenolase (IC50) was 1.49 mmol/L, much lower than the current commonly used arbutin (IC50) = 5.3 mmolL). In addition, methyl cinnamate is highly safe and has been widely used in daily flavors and food flavors, and is considered to be a very promising tyrosinase inhibitor.

Company Contact:

  • Phone: +8615549462710

  • Address: zhao bao road 1703, jiangan district, Wuhan, Hubei, China

  • Email: Email

Published date: August 14, 2019 -

  • Business Description: The company's main products are: cinnamic acid, cinnamaldehyde, cinnamon alcohol, methyl cinnamate, ethyl cinnamate, benzaldehyde and so on. The company has passed ISO9001 quality management system certification, and relying on the concept of independent development and joint development of universities, it has in-depth cooperation with major universities and scientific research institutions in Wuhan. It has successively obtained excellent companies with integrity standards, top ten outstanding private enterprises, and corporate credit evaluation AAA. Grade credit companies, etc.

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